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47th Annual Meeting of the Brazilian Biophysical Society_edited.jpg

Satellite Meetings

01.10 (9h -12h e 14h -17h) e 02.10 ( 9h - 12h) Instituto de Física, USP, São Paulo - Prof. Manuela Leal e prof. Pedro Torres

 

The short course will cover comparative modeling techniques using Modeller and AlphaFold software and then molecular dosing and virtual screening techniques will be used using mainly VINA software. Various conceptual aspects will be covered, such as Homology, Identity, Similarity, Sequence Alignment, Ramachandran Chart, Structural levels of Proteins, Protein Domains, Formation of Oligomers. For the dosage part we will cover Search Algorithms, Scoring Methods, Conformational Space, Chemical Space, Force Fields, Consensus Methods, Enrichment Factor, ROC Curve. Chemoinformatics methods and ADMETox Predictors will also be used.

MINICOURSE: Molecular biocondensates: from basic principles to examples in Cellular Biology

02.10 (13h - 16h30) Instituto de Física, USP, São Paulo - Prof. Anderson Pinheiro e Prof. Antonio Costa

Summary: (1) Transitions and phase separations in Nature (2) Biocondensates: a timeline (3) Thermodynamic fundamentals (4) Examples of biocondensates in Biochemistry and Cell Biology

MINICOURSE: Nanomedicine and biological barriers: from structural evaluation to in vitro/ex vivo methods

01.10 (9h - 12h | 14h - 17h) Instituto de Física, USP, São PauloCristina Padula (University of Parma, Italy), Aryane Alves Vigato (University of Malmö, Sweden), Daniele Ribeiro de Araujo (Federal University of Sao Paulo, Brazil)

 

Over the years, the biomedical field has seen significant advancements in the application of nanostructures, driven by their unique physicochemical properties and their ability to modulate biological effects. Nanostructures present advantageous characteristics like memory and fluidity effects, which enable them to overcome biological barriers, such as mechanical resistance and bioadhesion. This makes them suitable for various applications, including mucous, skin, joint viscosupplementation, and accessing or repairing blood vessels. Understanding these principles is crucial for designing nanostructured systems with optimized physicochemical stability, predicting in vivo dissolution processes, controlling opsonization, modulating release kinetics, and enhancing permeation of bioactives in physiological and pathological conditions. This minicourse focuses on the development of nanostructured systems, studied by biophysical techniques, to regulate bioactives in vitro and ex vivo permeation across biological barriers and intact or damaged tissues.

This is the third installment of the Current Topics in Molecular Biophysics symposia. These meetings draw leaders in the area of exerimental and theoretical molecular biophysics, in order to discuss recent major advances and questions in the field. The first two events were in 2014 and 2018, and then we had a rather long break due to the pandemic. With everything getting back to normal, we are excited to get this meeting back together, so that we can all meet up again soon!

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